Mehdipour scored the solitary goal of the match with a powerful shot just two minutes into the second half in Tehran’s Azadi Stadium.
Esteghlal cemented their place in top with 35 points, four points ahead of Sepahan.
On Thursday, Aluminum football team edged past Persepolis 1-0 in Arak.
Amir Nouri found the back of the net in the 75th minute.
In Isfahan, Malavan defeated Zob Ahan 1-0, Paykan and Nassaji shared the spoils in a 1-1 draw in Tehran, Shams Azar and Esteghlal Khuzestan played out a goalless draw in Qazvin and Mes were held by Havadar to a 0-0 draw in Rafsanjan.
MNA/TT