The accident occurred at around 5:00 pm (1700 GMT) at a bridge crossing the Bagoe River, it added, Channels TV reports.
“A bus… that was leaving Kenieba commune for Burkina Faso tipped off a bridge. The likely cause is the driver losing control of the vehicle,” the ministry said in a statement.
Automobile accidents are frequent in Mali, where many roads and highways as well as vehicles are in poor condition.
Earlier this month, 15 people were killed and 46 injured when a bus heading toward the capital Bamako collided with a truck in central Mali.
MNA/