The Chinese Consulate General in Toronto has confirmed that the four teenagers aged 15-17 are international students from China, Xinhua reports.
Police said the crash occurred on Highway 60, near Hidden Valley Road, at approximately 11:10 p.m. local time (1610 GMT), between a westbound Mercedes SUV and an eastbound Ford SUV.
Police said the teenagers were inside the Mercedes and pronounced dead at the scene.
A 42-year-old woman was driving the Ford SUV and succumbed to her injuries after being transported to hospital, the police said.
PR/