Nine people were killed, including seven children, when fighter jets struck a house in Khan Younis south of Gaza City, state news agency Wafa reported.
Several people reportedly remain trapped under the rubble.
More than 30 Palestinians were also killed and dozens injured in Israeli airstrikes in Rafah in the southern Gaza Strip, witnesses said.
A Palestinian baby lost his life and several people were injured in an airstrike in the Nuseirat refugee camp in central Gaza, according to witnesses.
A child was also killed in an Israeli air raid west of Khan Younis, Palestinian medical sources said.
Israeli warplanes also struck a house in the Tal al-Sultan neighborhood in Rafah amid reports of fatalities.
The conflict in Gaza, under Israeli bombardment and blockade since Oct. 7, began when Hamas initiated Operation Al-Aqsa Flood, a multi-pronged surprise attack that included a barrage of rocket launches and infiltration into Israel by land, sea, and air. It said the incursion was in retaliation for the storming of the Al-Aqsa Mosque and growing violence by Israeli settlers.
The Israeli military then launched Operation Swords of Iron against Hamas targets in the Gaza Strip.
Gaza is experiencing a dire humanitarian crisis with no electricity, while water, food, fuel, and medical supplies are running out.
At least 3,478 Palestinians have been killed in Israeli attacks on Gaza, while the figure stands at more than 1,403 settlers in Occupied Lands.
A medical source has told Al Jazeera that 121 people have been killed and 540 injured in the Gaza Strip since yesterday evening.
The Israeli army says at least 306 of its soldiers have died since Hamas’s attack in Israel on October 7.
Overall, at least 1,403 Israelis have been killed since the war started and about 4,629 injured.
RHM/PR