The victims include the pilot and two people on the ground, NBC News reported citing the US Federal Aviation Administration.
The crash happened around 7 p.m. and firefighters worked through the night on hot spots to get to the victims.
The plane was mostly in one home, Clearwater Fire Chief Scott Ehlers said.
At least three homes had fire damage, Ehlers said. Aside from the home that was directly struck, the people in the other homes were able to get out, he said.
AMK/PR